導(dǎo)師簡(jiǎn)介
姓名:王東文 性別:男 政治面貌:中共黨員
學(xué)歷:研究生 學(xué)位:博士 職稱(chēng):教授
博、碩導(dǎo)師:博士研究生導(dǎo)師 本崗位工作年數(shù):38年
研究方向:泌尿男生殖系腫瘤精準(zhǔn)診療的臨床及基礎(chǔ)研究
榮譽(yù)稱(chēng)號(hào):獲評(píng)新世紀(jì)“百千萬(wàn)”人才國(guó)家級(jí)人選、國(guó)務(wù)院特殊津貼專(zhuān)家、衛(wèi)生部有突出貢獻(xiàn)中青年專(zhuān)家、深圳市國(guó)家級(jí)領(lǐng)軍人才。榮獲教育部等十余項(xiàng)科技進(jìn)步獎(jiǎng),連續(xù)5年入選“中國(guó)名醫(yī)百?gòu)?qiáng)榜”,吳階平泌尿外科醫(yī)學(xué)獎(jiǎng)、首屆“白求恩式好醫(yī)生”提名獎(jiǎng)、中國(guó)泌尿腫瘤MDT卓越導(dǎo)師、南粵好醫(yī)生、第三屆深圳好醫(yī)生。
學(xué)術(shù)任職:深圳市抗癌協(xié)會(huì)泌尿男生殖系腫瘤專(zhuān)委會(huì)主委,國(guó)家癌癥中心國(guó)家腫瘤質(zhì)控中心膀胱癌質(zhì)控專(zhuān)委會(huì)副主委,中國(guó)醫(yī)療保健國(guó)際交流促進(jìn)會(huì)泌尿健康促進(jìn)分會(huì)副主委,中國(guó)醫(yī)學(xué)裝備協(xié)會(huì)泌尿外科分會(huì)(CUEA)副會(huì)長(zhǎng),中華醫(yī)學(xué)會(huì)泌尿外科分會(huì)(CUA)激光學(xué)組副組長(zhǎng),中國(guó)抗癌協(xié)會(huì)人工智能專(zhuān)業(yè)委員會(huì)常委,《中華腔鏡泌尿外科雜志》、《現(xiàn)代泌尿生殖腫瘤雜志》副主編。
近五年承擔(dān)科研課題情況:
1.ICG共軛偶聯(lián)PSMA在機(jī)器人/腹腔鏡前列腺癌手術(shù)治療中實(shí)時(shí)精準(zhǔn)定位及特異性研究,國(guó)家癌癥中心,2020.01-2023.12,300萬(wàn),主持,在研;
2.纖維細(xì)胞外泌體中內(nèi)質(zhì)網(wǎng)應(yīng)激相關(guān)凋亡miRNA介導(dǎo)糖尿病膀胱進(jìn)展的分子機(jī)制研究,國(guó)自然面上項(xiàng)目,2020.01-2023.12,55萬(wàn),主持,在研;
3.腺相關(guān)病毒對(duì)糖尿病膀胱基因治療的應(yīng)用及機(jī)制研究,國(guó)自然青年基金,2019.01-2021.12,22萬(wàn),參與人(導(dǎo)師);
4. 泌尿外科精準(zhǔn)診療及整合一體化的基礎(chǔ)與臨床研究,省教育廳重點(diǎn)項(xiàng)目1331工程,2019.04-2022.12,100萬(wàn),主持,已結(jié)題;
5. 達(dá)芬奇機(jī)器人手術(shù)淋巴組織熒光顯像技術(shù)在多學(xué)科腫瘤手術(shù)中的應(yīng)用研究,省科技廳重點(diǎn)研發(fā)計(jì)劃,2018.12-2020.12,80萬(wàn),主持,已結(jié)題;
代表性論著及近五年的代表性論文(限10項(xiàng)以內(nèi)):
1.《銩激光治療機(jī)團(tuán)體標(biāo)準(zhǔn)及其臨床應(yīng)用操作指南》,中國(guó)醫(yī)藥科技出版社,2021,主編。
2.《中國(guó)泌尿外科和男科疾病診斷治療指南》(2019版),科學(xué)出版社, 2020,分篇副主編。
3.“十三五”國(guó)家重點(diǎn)圖書(shū)出版規(guī)劃項(xiàng)目《吳階平泌尿外科學(xué)》,人民衛(wèi)生出版社, 2019,分篇副主編。
4.Liu HP, Zhang JV, Wang D, Albrecht A, Steinh?fel K, Lai HM. Extended endocrine therapy in breast cancer: A basket of length-constraint feature selection metaheuristics to balance Type I against Type II errors. J Biomed Inform. 2022;131:104112.
5.Liu HP, Wang D, Lai HM. Can we infer tumor presence of single cell transcriptomes and their tumor of origin from bulk transcriptomes by machine learning? Comput Struct Biotechnol J. 2022 May 23;20:2672-2679.
6.Xue B, Guo WM, Jia JD, Kadeerhan G, Liu HP, Bai T, Shao Y, Wang DW. MUC20 as a novel prognostic biomarker in ccRCC correlating with tumor immune microenvironment modulation. Am J Cancer Res. 2022 Feb 15;12(2):695-712.
7.Wu B, Lu X, Shen H, Yuan X, Wang X, Yin N, Sun L, Shen P, Hu C, Jiang H, Wang D. Intratumoral heterogeneity and genetic characteristics of prostate cancer. Int J Cancer. 2020 Jun 15;146(12):3369-3378.
8.Zhang L, Liu X, Xia R, et al. Comparison of the clinicopathologic features of prostate cancer in US and Chinese populations. Pathol Res Pract. 2022;234:153933.
9.Hao H, Chen H, Xie L, Liu H, Wang D. LncRNA KCNQ1OT1 Promotes Proliferation, Invasion and Metastasis of Prostate Cancer by Regulating miR-211-5p/CHI3L1 Pathway. Onco Targets Ther. 2021;14:1659-1671.
10.Wang D, Yuan X, Hu C, et al. Endoplasmic reticulum stress is involved in apoptosis of detrusor muscle in streptozocin-induced diabetic rats. Neurourol Urodyn. 2017;36(1):65-72.